Protein Details: Cyclic nucleotide-gated ion channel 17

Protein ID

ICDB_Pro_1268

Protein Name

Cyclic nucleotide-gated ion channel 17

Gene Name

CNGC17 At4g30360 F17I23_300

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

720 amino acids

AlphaFoldDB

AF-Q8L7Z0-F1-model_v4.pdb

Function

Probable cyclic nucleotide-gated ion channel. Forms a functional cation-translocating unit with AHAs that is activated by PSKR1/BAK1 and possibly other BAK1/RLK complexes. Required for PSK-induced protoplast expansion.

Sequence

MELRKDKLLMFYSEGKESKEAKWAVNDPMSKSYKLSLPSALRPDNLLPGNRLRYTDASKSKSSKVSWYKTILDPGSEIVLKWNWVFIVSCMVALFIDPLYFFVPAIGGDKNYPCARTDTSLSILVTFFRTIADLFYLLHIFIKFRTGFIAPNSSTRVFGRGELVMDPKAIAWRYIKSDFIIDLIATLPLPQIVIWFVISTTKSYRFDHNNNAIALIVLLQYIPRFYLIIPLSSQIVKATGVVTKTAWAGAAYNLLLYMLASHVLGAAWYILSVDRYTSCWKSRCNGEAGQVNCQLYYLDCDSMYDNNQMTWANVTKVFKLCDARNGEFKYGIFGNAITKNVVSSQFFERYFYCLWWGLQQLSSYGQNLSTTMFMGETTFAVLIAIFGLVLFAHLIGNMQTYLQSLTVRLEEWRLKKRDTEEWMRHRQLPEELRNRVRRYEQYKWLATRGVDEEVLLQSLPTDLRRDIQRHLCLDLVRRVPFFSQMDDQLLDAICERLVSSLCTEGTYLVREGDLISEMLFIIRGRLESSTTNGGRTGFFNSIILRPGDFCGEELLSWALLPKSTLNLPSSTRTVRALVEVEAFALRAEDLKFVANQFRRLHSKKLQHTFRFYSHHWRTWAACFIQAAWRRYKRRVMENNLTAIESMENEEGEVGEELVVVEEEECVEESPRTKMNLGVMVLASRFAANTRRGVAAQRVKDVELPRFKKPEEPDFSAEHDD

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 481..605; /ligand="a nucleoside 3,5-cyclic phosphate"; BINDING 552; /ligand="a nucleoside 3,5-cyclic phosphate"

Disease

Location

DOI ID

10.1038/47134; 10.1111/tpj.13415; 10.1126/science.1088305; 10.1104/pp.126.4.1646; 10.1105/tpc.15.00306

RefSeq

NP_194765.2